Faculty Expert Profile
- Assistant Professor of Chemistry
- Zanvyl Krieger School of Arts and Sciences
Stephen Fried studies how misfolded proteins in neurons affect disease progression and cognitive decline. During the coronavirus pandemic, Fried helped lead research into SARS-CoV-2 and a portion of its RNA to identify ways to block an important mechanism relating to viral replication.
Fried's lab works to interpret how proteins fold and assemble into complex molecular structures. His lab recently identified a cohort of proteins in E. coli that cannot refold even in the presence of molecular chaperones, which recognize and undo folding mistakes. These results may have applications for understanding aging.