Johns Hopkins surgeons perform world's first total penis and scrotum transplant

Many soldiers returning from combat bear visible scars, or even lost limbs, caused by blasts from improvised explosive devices, or IEDs. Some servicemen also return with debilitating hidden injuries—the loss of all or part of their genitals.

The Johns Hopkins reconstructive surgery team that performed the country's first bilateral arm transplant in a wounded warrior has now successfully performed the first total penis and scrotum transplant in the world, Johns Hopkins Medicine announced today. A team of nine plastic surgeons and two urological surgeons was involved in the 14-hour surgery on March 26. They transplanted from a deceased donor the entire penis, scrotum (without testicles) and partial abdominal wall.

"We are hopeful that this transplant will help restore near-normal urinary and sexual functions for this young man," says W.P. Andrew Lee, professor and director of plastic and reconstructive surgery at Johns Hopkins University's School of Medicine.

The recipient is a veteran who sustained injuries in Afghanistan and wishes to remain anonymous. He has recovered from the surgery and is expected to be discharged from the hospital this week.

"It's a real mind-boggling injury to suffer; it is not an easy one to accept," the recipient says. "When I first woke up, I felt finally more normal … [with] a level of confidence as well. Confidence … like finally I'm OK now."

Image credit: Johns Hopkins Medicine

While it's possible to reconstruct a penis using tissue from other parts of the body, Lee says, a prosthesis implant would be necessary to achieve an erection, and that comes with a much higher rate of infection. Additionally, due to other injuries, servicemen often don't have enough viable tissue from other parts of their bodies to work with.

This type of transplant, where a body part or tissue is transferred from one individual to another, is called vascularized composite allotransplantation. The surgery involves transplanting skin, muscles and tendons, nerves, bone, and blood vessels.

As with any transplant surgery, tissue rejection is a concern. The patient is put on a regimen of immunosuppressive drugs to prevent rejection. Lee's team has developed an immune modulation protocol aimed at minimizing the number of these drugs needed to prevent rejection.