Experts from Johns Hopkins University met today for a webcast discussion of the latest developments in the ongoing coronavirus outbreak, including efforts to study the virus and methods of reducing the spread of illness.
The conversation was moderated by Joshua Sharfstein, vice dean of public health practice and community engagement for the Bloomberg School of Public Health.
Virologist Andy Pekosz, an expert in microbiology and immunology, provided an update on the status of two vaccine trials, the first of which began this week in Washington state and the second of which is scheduled to begin within the next week.
"One of the amazing things that has happened scientifically with this outbreak is the speed in which vaccines have been designed and brought into the first phase of testing, which is the safety phase," Pekosz said. "These are just the very early stages of vaccine development, but it's only been two months that we've known what this virus was, and we already have a vaccine—I think that's a tremendous statement to the science behind this [effort]."
The goal of these trials, Pekosz explained, is to develop vaccines that resemble the virus SARS-CoV-2, which causes the disease COVID-19. These vaccines would generate antibodies that prevent the virus from infecting cells. Although it is difficult to predict how long it will take to develop a viable vaccine, Pekosz said it will likely be between 12 and 18 months.
In his laboratory at the Bloomberg School, Pekosz is working to understand how the virus infects cells and why it causes relatively mild respiratory disease compared to a related coronavirus, SARS, which caused an outbreak of very severe respiratory disease in 2002. These mild cases, Pekosz said, may be the key to understanding how to prevent more severe COVID-19 infections.
"My lab uses a cell culture system that mimics the upper respiratory tract of humans, and so we're really going to be studying how the virus replicates in that environment," Pekosz said. "By understanding some of the processes the virus uses to infect cells in the upper respiratory tract, that may give us some hints as to weak points in the life cycle that could be the targets for interventions."
He also discussed the widely publicized effort by Arturo Casadevall, a fellow Bloomberg School faculty member, to develop a COVID-19 treatment derived from the antibodies of people who have survived infection.
"There's a long history of using antibodies of people who have survived infection as a treatment, and there are some studies coming from China that suggest there is some utility to this treatment, so there are a number of institutions in the U.S. that are trying to gear up to see if they can get this into place," Pekosz said.
It's unclear whether those who have recovered from COVID-19 can become re-infected, he added. He also clarified common misconceptions about coronavirus and provided useful information about the virus, including:
- Evidence indicates that the virus can survive on surfaces for up to 24 hours.
- Vodka and scotch do not have high enough concentrations of alcohol to disinfect surfaces. It is more effective to use common disinfectants like rubbing alcohol or a 10:1 water to bleach solution.
- The primary avenue for virus transmission is through droplets formed during coughs or sneezes. These droplets primarily travel three to six feet and can land on surfaces where the virus can be spread to others.
- Although some respiratory diseases do decline in warmer months, there is not enough evidence at this time to indicate whether COVID-19 will decrease its spread as the summer months approach.
"I do think, in some respects, that we are just getting started [with community transmission] in the United States," Rivers said. "But that doesn't mean that we need to keep going [on that trajectory]."
She pointed to protective measures that have been put into place that can help reduce transmission. These measures, broadly called social distancing, are designed to limit physical exposure to other people in order to help lower the rate of transmission of disease. Social distancing can include:
- Washing your hands
- Remaining at home, especially if you are sick
- Avoiding contact with high-touch surfaces such as cart handles at the grocery store
- Maintaining three to six feet of physical distance from others
She even pointed to the measures she and her co-panelists took to reduce the risk of transmission in the webcast studio—namely maintaining a safe physical distance and wiping down table surfaces between interviews.
"I am encouraged by measures by communities to close down public spaces where people gather," she said. "In general, I do not recommend movement restrictions … but things like closing schools, gyms, mass gatherings—I think those are the right moves. But I think we all should continue in the spirit of those interventions—they're really to encourage and enable people to stay home."
This is a message especially important for younger people, Rivers said. Although young people are less likely to be susceptible to severe illness from COVID-19, they can transmit the disease to vulnerable populations who must venture into public spaces for errands.
"Young people play a really important role in breaking that chain of transmission," Rivers said.
Additionally, Rivers suggested people should:
- Cancel elective or non-urgent medical appointments when appropriate or when instructed by health care providers
- Avoid direct contact with others, including while playing sports (although she noted more solitary outdoor activities such as bike riding or hiking are safe)
- Turn to online resources for social interaction
"We all have an important role to play," Rivers said.