CS Seminar: Jian Ma

Description

Jian Ma, a professor of computational biology at Carnegie Mellon University's School of Computer Science, will give a talk titled "Integrative Modeling of Multiscale Single-Cell Spatial Epigenome" for the Department of Computer Science.

This is a hybrid event; the Zoom link is available on the event page.

Abstract:

Despite significant advancements in high-throughput data acquisition in genomics and cell biology, our understanding of the diverse cell types within the human body remains limited. Particularly, the principles governing intracellular molecular spatial organization and cellular spatial organization within complex tissues are still largely unclear. A major challenge lies in developing computational methods capable of integrating heterogeneous and multiscale molecular, cellular, and tissue information. In this talk, Jian Ma will discuss his recent work on creating integrative approaches for single-cell spatial epigenomics and transcriptomics. These methods hold the potential to reveal new insights into fundamental genome structure and cellular function, as well as the spatial organization of cells within complex tissues, across a wide range of biological contexts in health and disease.