DMSE Seminar Series: Su-Ryon Shin

Description

Su-Ryon Shin, an assistant professor of medicine in the Division of Engineering in Medicine at the Harvard Medical School Brigham and Women's Hospital, will give a talk titled "Micro/Nano Engineered Biomaterials for Manufacturing Biomimetic Tissues and Biomedical Applications" for the Department of Materials Science and Engineering.

Zoom meeting information is on the DMSE event page.

Abstract:

Engineered biomaterials have recently drawn a lot of attention for applications in various biomedical fields of research due to their high biocompatibility and similarity to a native extracellular matrix (ECM). To increase the utilization of biomaterials in these areas, composite or hybrid biomaterials incorporating nanomaterials and bioactive molecules have been developed to adjust the biological and physical properties of the biomaterials to resemble native tissues and to bring controlled release of biological compounds (e.g., drug and genes) to adapt to the criteria required for their specific applications. Also, the intricate heterogeneity in biological structures and the physical properties of native tissues/organs has intrigued a need for multi-material and multi-cellular hybrid designs. Therefore, advances in biomanufacturing techniques which can manipulate the structure of the engineered biomaterials were developed to recapitulate biological systems with adequate levels of functionality for tissue/organ remodeling and regeneration. Furthermore, to bring advanced functions such as the controlled release of drugs and the replication of organ functions, such as the sensory function of the nose, biocompatible electronic devices and biosensing platforms have been integrated into biomanufactured tissue constructs. Therefore, the hybrid system could be useful for creating multifunctional tissue/organ and biohybrid actuators for both therapeutic purposes and in vitro studies. The engineered 3D tissue constructs can be used for toxicity assays based on organs-on-a-chip platforms, which have become increasingly important for drug discovery.