Healthy participants needed for lung imaging research study

Johns Hopkins is recruiting healthy volunteers (18-60 years old) who have no known lung disease and who do not smoke or vape, and are not currently on any medications (prescription and nonprescription), for an imaging study that requires up to six visits over two months to our research center.

Most respiratory inhalers use a gas called a propellant to deliver medication to the lungs. Usually, inhalers use a propellant called hydrofluoroalkane (HFA), which has a negative impact on the environment. This study is looking at an alternative propellant that uses hydrofluoroolefin (HFO). It works similarly to HFA by delivering medication to the lungs, but it has a much less negative environmental impact. No medication is being tested in this study.

During these visits, you will be asked about your health and asked to do lung function tests and to have a brief physical exam, pregnancy test (if applicable), and a mucociliary clearance scan (MCC scan)—a test during which you inhale a very small amount of radioactive material while a camera images your lungs as you breathe. Participants will be reimbursed for their time and travel.

For more information, contact the research coordinator, Julia Peterson, at

Principal Investigator: Peter Mogayzel Jr., MD, PhD
Protocol: A Study to Assess the Effect of the HFO MDI Propellant on Mucociliary Clearance Compared to the HFA MDI Propellant in Healthy Participants