Faculty Expert Profile

Jeffrey Gray, a Johns Hopkins University Provost's Discovery Award recipient, is the creator of a pioneering computer code architecture used by thousands of biomedical researchers worldwide to predict and design protein structure. The computational tools he and his GrayLab develop are furthering capabilities to resolve disease and immunity, including cell signaling, DNA regulation, Alzheimer's disease, HIV, and cancer.

Gray is the original developer of RosettaDock, a multi-scale algorithm and leading tool for the prediction of the structure of protein complexes from their constituent proteins. Protein docking is critical for deciphering molecular mechanisms. Gray's team pioneered key methods in exploring diverse conformations, evaluating candidate structures, and deploying advanced optimization algorithms on supercomputing facilities to enable consistent and accurate results.