BME Virtual Weekly Seminar Series: Danilo Tagle

Description

Danilo Tagle, a director in the Office of Special Initiatives at the National Institutes of Health's (NIH) National Center for Advancing Translational Sciences, will give a talk titled "In Vitro 3D Models for Safety and Efficacy Studies" for the Department of Biomedical Engineering.

Deok-Ho Kim will be the faculty host.

Approximately 30% of drugs have failed in human clinical trials due to adverse reactions despite promising pre-clinical studies, and another 60% fail due to lack of efficacy. A number of these failures can be attributed to poor predictability of human response from animal and 2D in vitro models currently being used in drug development. To address this challenges in drug development, the NIH Tissue Chips or Microphysiological Systems program is developing alternative innovative approaches for more predictive readouts of toxicity and efficacy of candidate drugs. Tissue chips are bioengineered 3D microfluidic platforms utilizing chip technology and human-derived cells and tissues that are intended to mimic tissue cytoarchitecture and functional units of human organs and systems. In addition to toxicity studies in drug development, these microfabricated devices are also being used to model various human diseases for assessment of efficacy of candidate therapeutics. A more recent program is the development of "clinical trials on chips" to inform clinical trial design and implementation, and for studies in precision medicine. Presentation will provide a program update and also elaborate in the development and utility of microphysiologicals systems and in the partnerships with various stakeholders for its implementation.